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KMID : 1145120200180030389
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Asian Journal of Beauty and Cosmetology
2020 Volume.18 No. 3 p.389 ~ p.397
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Antioxidant and Anti-inflammatory Effects of Ginseng Berry Ethanol Extracts as a Cosmetic Ingredient
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Kim Hyeon-Suk
Ko Kyoung-Sook
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Abstract
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Purpose : This study was conducted to evaluate the applicability of ginseng berry in cosmetics.
Methods : Ethanol extract of ginseng berry was analyzed using gas chromatography-mass spectrometry (GC-MS). 2,2-Diphenyl-1-picrylhydrazyl (DPPH) scavenging was used to determine the antioxidant activity, total polyphenol, and flavonoid content. Cell viability (MTT assay) confirmation was conducted to determine the toxicity, while the anti-inflammatory effect was investigated by measuring the inhibition of nitric oxide (NO) production.
Results : The total polyphenol and flavonoid contents were 152±12.4 μg/mL and 50.16±1.48 μg/mL, respectively. DPPH scavenging activity in the extract with a concentration of 0.25 mg/mL increased to 59.21±4.20%, 0.5 mg/mL to 69.27±2.38%, and 1 mg/mL to 89.30±1.25%. Cell viability evaluation showed a survival rate of 80.92±5.77% for 1 mg/mL concentration range for cell viability evaluation?0.125?1 mg/mL. The inhibitory effect of nitric oxide (NO) production through RAW 264.7 cells induced by inflammatory response with lipopolysaccharide (LPS) resulted in an extract concentration of 25.58±3.11 μM (0.25 mg/mL), 13.91±3.86 μM (0.5 mg/mL), and 3.91±1.55 μM (1 mg/mL). The increase in concentration confirms an antiinflammatory effect.
Conclusion : Ethanol extract of ginseng berry has excellent antioxidant and anti-inflammatory effects and can be a functional cosmetic material.
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KEYWORD
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Ginseng berry, Antioxidant, Anti-inflammation, Polyphenol, Cosmetics
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